RAF Typhoon jets have joined forces with French aircraft in a coordinated attack on an underground arms cache in Syrian territory operated by the IS group, as stated by the British defence ministry.
The facility, located using reconnaissance, was believed to be storing arms and explosives, the statement said, and was positioned in hills just above the ancient city of Palmyra in central Syria.
"Our aircraft used laser-guided Paveway IV weapons to target a series of entry passages down to the facility... initial indications indicate the objective was successfully hit," the ministry announced.
There was no indication of any civilian impact in the operation on Saturday evening and every plane involved returned to base without incident, the defence officials confirmed.
The Typhoon FGR4s were supported by a Voyager aerial refuelling aircraft.
Daesh - alternatively referred to as Daesh - imposed extremist governance over significant areas in Iraq and Syria before its territorial defeat in 2019.
"This strike underscores British leadership, and resolve to stand shoulder to shoulder with our partners, to eliminate any resurgence of IS and their harmful and extremist ideologies in the area," the British Defence Secretary John Healey remarked.
RAF aircraft have conducted patrols over Syrian airspace to "forestall any attempted resurgence" of the group following its military defeat at the battle of Baghuz in 2019, the MoD reported.
"I want to thank the personnel of the UK armed forces who took part in this strike for their expertise and their bravery," he added. "Including them were a great many UK service members deployed over the festive period. This mission, to remove militants who endanger our safety, demonstrates how UK forces are prepared to act, continuously, keeping Britain secure within its borders and powerful internationally."
During December, the American forces executed what it described as a "massive strike" against Islamic State objectives in the country, following an assault killed two US servicemembers and a civilian interpreter in Palmyra.
The UN reports Islamic State still has between 5,000 and 7,000 militants in both countries.